Zoledronic acid is contraindicated in patients with the following conditions:
- Hypocalcemia [see Warnings and Precautions (5.2)]
- Creatinine clearance less than 35 mL/min and in those with evidence of acute renal impairment due to an increased risk of renal failure [see Warnings and Precautions (5.3)].
- Known hypersensitivity to zoledronic acid or any components of zoledronic acid. Hypersensitivity reactions including urticaria, angioedema, and anaphylactic reaction/shock have been reported [see Adverse Reactions (6.2)].